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Article

Population genomics of drug resistance in <i>Candida albicans</i>

27 Jun 2002

Abstract excerpt

We followed adaptation in experimental microbial populations to inhibitory concentrations of an antimicrobial drug. The evolution of drug resistance was accompanied in all cases by changes in gene expression that persisted in the absence of the drug; the new patterns of gene expression were constitutive. The changes in gene expression occurred in four replicate populations of the pathogenic fungus Candida...

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PMID: 12089321
DOI: 10.1073/pnas.102291099

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