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Article

<i>Candida albicans</i> genetic background influences mean and heterogeneity of drug responses and genome stability during evolution to fluconazole

2018-07-03

Abstract excerpt

The importance of within-species diversity in determining the evolutionary potential of a population to evolve drug resistance or tolerance is not well understood, including in eukaryotic pathogens. To examine the influence of genetic background, we evolved replicates of twenty different clinical isolates of Candida albicans, a human fungal pathogen, in fluconazole, the commonly used antifungal drug. The isolates...

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Identifiers and source

Literature Corpus work
ef64547f-f55d-5a14-a71f-937d3e414f06
DOI
10.1101/360347
Open publication

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<i>Candida albicans</i> genetic background influences mean and heterogeneity of drug responses and genome stability during evolution to fluconazoleDOI 10.1101/360347
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