Narrow mutational signatures drive acquisition of multidrug resistance in the fungal pathogen Candida glabrata.

doi:10.1016/j.cub.2021.09.084

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Article

Narrow mutational signatures drive acquisition of multidrug resistance in the fungal pathogen Candida glabrata.

Current biology : CB - 6 Dec 2021

Ksiezopolska Ewa, Schikora-Tamarit Miquel Àngel, Beyer Reinhard, Nunez-Rodriguez Juan Carlos, Schüller Christoph, Gabaldón Toni

Abstract excerpt

Fungal infections are a growing medical concern, in part due to increased resistance to one or multiple antifungal drugs. However, the evolutionary processes underpinning the acquisition of antifungal drug resistance are poorly understood. Here, we used experimental microevolution to study the adaptation of the yeast pathogen Candida glabrata to fluconazole and anidulafungin, two widely used antifungal drugs with...

Topics

Anidulafungin
Antifungal Agents
Candida glabrata
Drug Resistance, Fungal
Drug Resistance, Multiple
Fluconazole
Microbial Sensitivity Tests
Mutation

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Identifiers

PMID: 34699784
DOI: 10.1016/j.cub.2021.09.084
PMCID: PMC8660101

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