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Article

Candida albicans Genetic Background Influences Mean and Heterogeneity of Drug Responses and Genome Stability during Evolution in Fluconazole.

mSphere - 24 Jun 2020

Gerstein Aleeza C, Berman Judith

Abstract excerpt

The importance of within-species diversity in determining the evolutionary potential of a population to evolve drug resistance or tolerance is not well understood, including in eukaryotic pathogens. To examine the influence of genetic background, we evolved replicates of 20 different clinical isolates of Candida albicans, a human fungal pathogen, in fluconazole, the commonly used antifungal drug. The isolates...

Topics

Antifungal Agents
Candida albicans
Candidiasis
Directed Molecular Evolution
Drug Resistance, Fungal
Fluconazole
Genetic Background
Genetic Fitness
Genome, Fungal
Genomic Instability
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microbial Sensitivity Tests

Mutation

Phenotype

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Identifiers

PMID: 32581072
DOI: 10.1128/mSphere.00480-20
PMCID: PMC7316494

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