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Article

The evolution of drug resistance in clinical isolates of Candida albicans.

eLife - 3 Feb 2015

Ford Christopher B, Funt Jason M, Abbey Darren, Issi Luca, Guiducci Candace, Martinez Diego A, Delorey Toni, Li Bi Yu, White Theodore C, Cuomo Christina, Rao Reeta P, Berman Judith, Thompson Dawn A, Regev Aviv

Abstract excerpt

Candida albicans is both a member of the healthy human microbiome and a major pathogen in immunocompromised individuals. Infections are typically treated with azole inhibitors of ergosterol biosynthesis often leading to drug resistance. Studies in clinical isolates have implicated multiple mechanisms in resistance, but have focused on large-scale aberrations or candidate genes, and do not comprehensively chart...

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Identifiers

PMID: 25646566
DOI: 10.7554/eLife.00662
PMCID: PMC4383195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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