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Article

Evolution of antifungal-drug resistance: mechanisms and pathogen fitness.

Nature reviews. Microbiology - 1 Jul 2005

Anderson James B

Abstract excerpt

Like other microorganisms, fungi exist in populations that are adaptable. Under the selection imposed by antifungal drugs, drug-sensitive fungal pathogens frequently evolve resistance. Although the molecular mechanisms of resistance are well-characterized, there are few measurements of the impact of these mechanisms on pathogen fitness in different environments. To predict resistance before a new drug is...

Topics

Antifungal Agents
Biological Evolution
Candida albicans
Drug Resistance, Fungal
Epistasis, Genetic
Forecasting
Fungi
Humans
Microbial Sensitivity Tests
Mutation
Saccharomyces cerevisiae
Virulence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15953931
DOI: 10.1038/nrmicro1179

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