Article

Polygenetic Determinants of Azole Resistance, Tolerance, and Heteroresistance in <i>Candida albicans</i>

2025-06-29

Abstract excerpt

<h4>ABSTRACT</h4> Azole antifungals are widely used to treat Candida infections, yet therapeutic failures are common. In addition to resistance, fungal populations can exhibit tolerance and heteroresistance, subpopulation-driven drug responses that can contribute to treatment failure. Here, we performed a genome-wide association study (GWAS) on 557 genetically diverse C. albicans isolates to identify genetic lo...

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Literature Corpus work: e5ad04d1-8d0b-5455-96d7-94481f57f260
DOI: 10.1101/2025.06.29.662174

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