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A three‐dimensional spheroid co‐culture system of neurons and astrocytes derived from Alzheimer's disease patients for drug efficacy testing

11 Jan 2023

Abstract excerpt

Cell culture systems derived from the progenitor cells of human patients have many advantages over animal models for therapeutic drug testing and studies of disease pathogenesis. Here we describe a three-dimensional (3D) spheroid co-culture system of neurons and astrocytes derived from induced pluripotent stem cells-neural precursor cells (iPSCs-NPCs) of Alzheimer's disease (AD) patients or healthy individuals...

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PMID: 36628615
DOI: 10.1111/cpr.13399

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