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Article

Alzheimer's disease in a dish: promises and challenges of human stem cell models.

Human molecular genetics - 15 Oct 2012

Young Jessica E, Goldstein Lawrence S B

Abstract excerpt

Human pluripotent stem cells can differentiate into disease-relevant cell types, which capture the unique genome of an individual patient and provide insight into pathological mechanisms of human disease. Recently, human stem cell models for Alzheimer's disease (AD), the most common neurodegenerative dementia, have been described. Stem cell-derived neurons from patients with familial and sporadic AD and Down's...

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Identifiers

PMID: 22865875
DOI: 10.1093/hmg/dds319
PMCID: PMC3459645

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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