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Article

Altered expression of K13 disrupts DNA replication and repair in Plasmodium falciparum

29 Nov 2018

Abstract excerpt

BACKGROUND: Plasmodium falciparum exhibits resistance to the artemisinin component of the frontline antimalarial treatment Artemisinin-based Combination Therapy in South East Asia. Millions of lives will be at risk if artemisinin resistance (ART-R) spreads to Africa. Single non-synonymous mutations in the propeller region of PF3D7_1343700,"K13" are implicated in resistance. In this work, we use transcriptional...

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PMID: 30486796
DOI: 10.1186/s12864-018-5207-7

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