Article
K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair.
Cell reports - 4 Aug 2020
Xiong Aoli, Prakash Prem, Gao Xiaohong, Chew Marvin, Tay Ian Jun Jie, Woodrow Charles J, Engelward Bevin P, Han Jongyoon, Preiser Peter R
Abstract excerpt
Southeast Asia has been the hotbed for the development of drug-resistant malaria parasites, including those with resistance to artemisinin combination therapy. While mutations in the kelch propeller domain (K13 mutations) are associated with artemisinin resistance, a range of evidence suggests that other factors are critical for the establishment and subsequent transmission of resistance in the field. Here, we...
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