Insights into the factors contributing to artemisinin resistance in Plasmodium falciparum.

doi:10.1093/trstmh/trag049

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Article

Insights into the factors contributing to artemisinin resistance in Plasmodium falciparum.

Transactions of the Royal Society of Tropical Medicine and Hygiene - 5 Aug 2026

Sharma Priyanka, Verma Kanika, Tyagi Suchi, Singh Kuldeep, Bharti Praveen Kumar

Abstract excerpt

Artemisinin (ART)-based combination therapies are instrumental in reducing the burden of malaria worldwide. However, the emergence of ART resistance (ARTR) threatens the elimination of malaria. Understanding the mechanisms regulating ARTR is essential for developing effective strategies to prevent malaria. While various mutations in the Plasmodium falciparum Kelch13 gene, particularly in the propeller domain, are...

Topics

Artemisinins
Plasmodium falciparum
Drug Resistance
Humans
Antimalarials
Malaria, Falciparum
Mutation
Unfolded Protein Response
Protozoan Proteins

Source

Open in PubMed

Identifiers

PMID: 42033324
DOI: 10.1093/trstmh/trag049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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