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Article

Multi-omics dissection of stage-specific artemisinin tolerance mechanisms in Kelch13-mutant Plasmodium falciparum.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Sept 2023

Chen Jiayun, Gao Peng, Xiao Wei, Cheng Guangqing, Krishna Sanjeev, Wang Jianyou, Wong Yin Kwan, Wang Chen, Gu Liwei, Yang Dong Hua, Wang Jigang

Abstract excerpt

AIMS: We investigated the stage-specific mechanisms of partial resistance to artemisinin (ART, an antimalarial drug) in Plasmodium falciparum (P. falciparum) carrying the Kelch13 C580Y mutation. METHODS: Using fluorescence labeling and activity-based protein profiling, we systematically profile the ART activation levels in P. falciparum during the entire intra-erythrocytic developmental cycle (IDC), and...

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PMID: 37385107
DOI: 10.1016/j.drup.2023.100978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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