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Article

Structural mapping of Kelch13 mutations associated with artemisinin resistance in malaria.

Journal of structural and functional genomics - 1 Sept 2016

Singh Gajinder Pal, Goel Preeti, Sharma Amit

Abstract excerpt

Mutations in Plasmodium falciparum gene kelch13 (pfkelch13) are strongly and causally associated with resistance to anti-malarial drug artemisinin, but their effects on PfKelch13 structure and function remain unclear. Utilizing the publicly available three-dimensional structure of PfKech13 (PDB ID: 4yy8), we find that most of the mutations in its propeller domain occur in two spatial clusters. Of these, one...

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Identifiers

PMID: 27400688
DOI: 10.1007/s10969-016-9205-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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