Article
Surveillance of artemisinin resistance in Plasmodium falciparum in India using the kelch13 molecular marker.
Antimicrobial agents and chemotherapy - 1 May 2015
Mishra Neelima, Prajapati Surendra Kumar, Kaitholia Kamlesh, Bharti Ram Suresh, Srivastava Bina, Phookan Sobhan, Anvikar Anupkumar R, Dev Vas, Sonal Gagan Singh, Dhariwal Akshay Chandra, White Nicholas J, Valecha Neena
Abstract excerpt
Malaria treatment in Southeast Asia is threatened with the emergence of artemisinin-resistant Plasmodium falciparum. Genome association studies have strongly linked a locus on P. falciparum chromosome 13 to artemisinin resistance, and recently, mutations in the kelch13 propeller region (Pfk-13) were strongly linked to resistance. To date, this information has not been shown in Indian samples. Pfk-13 mutations...
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