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Article

Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

12 Dec 2014

Abstract excerpt

Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain-carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptomes of 1043 P. falciparum isolates from patients with acute malaria and found that artemisinin resistance is associated...

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PMID: 25502316
DOI: 10.1126/science.1260403

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