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Immune environment and antigen specificity of the T cell receptor repertoire of malignant ascites in ovarian cancer

6 Jan 2023

Abstract excerpt

We evaluated the association of disease outcome with T cell immune-related characteristics and T cell receptor (TCR) repertoire in malignant ascites from patients with high-grade epithelial ovarian cancer. Ascitic fluid samples were collected from 47 high-grade epithelial ovarian cancer patients and analyzed using flow cytometry and TCR sequencing to characterize the complementarity determining region 3 TCR...

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PMID: 36607962
DOI: 10.1371/journal.pone.0279590

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