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The mutational landscape defines the proteome and spatial organization of tumor, stroma and immune cells in ovarian cancer

2025-06-03

Abstract excerpt

High-grade serous ovarian cancer (HGSOC) is a highly aggressive and lethal form of ovarian cancer. Challenges to diagnosis and treatment include a lack of effective screening methods for early detection, the absence of cancer-specific symptoms, and the development of chemoresistance. The genomic instability of HGSOC, further complicated by homologous recombination deficiency (HRD), leads to heterogeneity in HGSOC...

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Literature Corpus work
048658e1-5305-58ee-ab24-27cad08bca11
DOI
10.1101/2025.06.01.655822
Open publication

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