Article

T cell-Macrophage Interactions Potentially Influence Chemotherapeutic Response in Ovarian Cancer Patients

2026-03-04

Abstract excerpt

<h4>ABSTRACT</h4> Tumor development and progression involve complex cell-cell interactions and dynamic co-evolution between cancer cells, immune cells and stromal cells in the tumour microenvironment, and this may influence therapeutic resistance. A large proportion of this network relies on direct physical interactions between cells, particularly T-cell mediated interactions. Cell-cell communication inference ha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2acf7cb7-ce8f-5c07-9edf-2d307bf7430c
DOI: 10.64898/2026.03.02.709041

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

T cell-Macrophage Interactions Potentially Influence Chemotherapeutic Response in Ovarian Cancer PatientsDOI 10.64898/2026.03.02.709041Read

Chemotherapy induces myeloid-driven spatial T-cell exhaustion in ovarian cancerSemantic proximity Read

Physical cell-cell interactions regulate transcriptional programmes that control the responses of high grade serous ovarian cancer patients to therapySemantic proximity Read

Identification of the immune subtype of ovarian cancer patients by integrated analyses of transcriptome and single-cell sequencing dataSemantic proximity Read

Exhausted CD8⁺ T Cells Promote Ovarian Cancer Immunosuppression via CCL3-Driven M2 Macrophage PolarizationSemantic proximity Read

Single-cell RNA sequencing reveals that MYBL2 in malignant epithelial cells is involved in the development and progression of ovarian cancerSemantic proximity Read

Systems-Level Mapping of the Tumor Microenvironment Reveals Immune-Mediated Mechanisms and Potential Targets in Platinum-Resistant Ovarian CancerSemantic proximity Read

Integration of scRNA-Seq and bulk RNA-Seq to Establish a Macrophage-related Prognostic Model in Ovarian CancerSemantic proximity Read

Mapping ovarian cancer spatial organization uncovers immune evasion drivers at the genetic, cellular, and tissue levelSemantic proximity Read

Ovarian cancer-associated immune exhaustion involves SPP1+ T cell and NKT cell, symbolizing more malignant progressionSemantic proximity Read

Single-Cell Transcriptomics Reveals Tissue Architecture in Ovarian CarcinosarcomaSemantic proximity Read

Single-cell analysis revealed that IL4I1 promoted ovarian cancer progressionSemantic proximity Read

Mapping intratumoral myeloid-T cell interactomes at single-cell resolution reveals targets for overcoming checkpoint inhibitor resistanceSemantic proximity Read