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Ovarian cancer is detectable from peripheral blood using machine learning over T-cell receptor repertoires

22 Jan 2024

Abstract excerpt

The extraordinary diversity of T cells and B cells is critical for body maintenance. This diversity has an important role in protecting against tumor formation. In humans, the T-cell receptor (TCR) repertoire is generated through a striking stochastic process called V(D)J recombination, in which different gene segments are assembled and modified, leading to extensive variety. In ovarian cancer (OC), an...

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PMID: 38483254
DOI: 10.1093/bib/bbae075

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