Article
Impact of cancer-associated mutations in CC chemokine receptor 2 on receptor function and antagonism.
Biochemical pharmacology - 1 Feb 2023
den Hollander L S, Béquignon O J M, Wang X, van Wezel K, Broekhuis J, Gorostiola González M, de Visser K E, IJzerman A P, van Westen G J P, Heitman L H
Abstract excerpt
CC chemokine receptor 2 (CCR2), a G protein-coupled receptor, plays a role in many cancer-related processes such as metastasis formation and immunosuppression. Since ∼ 20 % of human cancers contain mutations in G protein-coupled receptors, ten cancer-associated CCR2 mutants obtained from the Genome Data Commons were investigated for their effect on receptor functionality and antagonist binding. Mutations were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.