Article

Pan-cancer in silico analysis of somatic mutations in G-protein coupled receptors: The effect of evolutionary conservation and natural variance

2021-10-26

Abstract excerpt

G protein-coupled receptors (GPCRs) form the most frequently exploited drug target family, moreover they are often found mutated in cancer. Here we used an aggregated dataset of mutations found in cancer patient samples derived from the Genomic Data Commons and compared it to the natural human variance as exemplified by data from the 1000 Genomes project. While the location of these mutations across the protein do...

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Literature Corpus work: cc05bc45-ae82-540c-8968-5b75e0d7e8c9
DOI: 10.1101/2021.10.25.465693

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