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Article

Mapping Interaction Sites on Human Chemokine Receptors by Deep Mutational Scanning.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2018

Heredia Jeremiah D, Park Jihye, Brubaker Riley J, Szymanski Steven K, Gill Kevin S, Procko Erik

Abstract excerpt

Chemokine receptors CXCR4 and CCR5 regulate WBC trafficking and are engaged by the HIV-1 envelope glycoprotein gp120 during infection. We combine a selection of human CXCR4 and CCR5 libraries comprising nearly all of ∼7000 single amino acid substitutions with deep sequencing to define sequence-activity landscapes for surface expression and ligand interactions. After consideration of sequence constraints for...

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Share to Receptors, CXCR4
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chemokine CCL5

Share to HIV Envelope Protein gp120

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Source

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Identifiers

PMID: 29678950
DOI: 10.4049/jimmunol.1800343
PMCID: PMC5964024

Genes

CXCR4
CCR5
CXCL12
CCL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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