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Article

Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2.

The Journal of biological chemistry - 19 Sept 2003

Alvarez Arias Diana, Navenot Jean-Marc, Zhang Wen-Bo, Broach James, Peiper Stephen C

Abstract excerpt

CCR5 is a G protein-coupled receptor for RANTES, MIP-1alpha, MIP-1beta, and MCP-2 that functions as the front line coreceptor for human immunodeficiency virus type 1 infection. To elucidate the mechanism for CCR5 activation, this coreceptor was expressed in yeast coupled to the pheromone response pathway and a constitutively active mutant (CAM) was derived by random mutagenesis. Conversion of Thr-82 in the highly...

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Source

Identifiers

PMID: 12837756
DOI: 10.1074/jbc.M303739200

Genes

CCR5
CCR2
MIP
CCR1
CCR3
CCR4
CXCR2
CXCR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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