Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of cancer-related somatic mutations in the adenosine A2B receptor.

European journal of pharmacology - 5 Aug 2020

Wang Xuesong, Jespers Willem, Bongers Brandon J, Habben Jansen Maria C C, Stangenberger Chantal M, Dilweg Majlen A, Gutiérrez-de-Terán Hugo, IJzerman Adriaan P, Heitman Laura H, van Westen Gerard J P

Abstract excerpt

In cancer, G protein-coupled receptors (GPCRs) are involved in tumor progression and metastasis. In this study we particularly examined one GPCR, the adenosine A2B receptor. This receptor is activated by high concentrations of its endogenous ligand adenosine, which suppresses the immune response to fight tumor progression. A series of adenosine A2B receptor mutations were retrieved from the Cancer Genome Atlas...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminopyridines
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Mutation

Share to Neoplasms

Share to Saccharomyces cerevisiae

Source

Identifiers

PMID: 32348778
DOI: 10.1016/j.ejphar.2020.173126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of cancer-related somatic mutations in the adenosine A2B receptor.PMID 32348778Read ↗

Cancer-related somatic mutations alter adenosine A1 receptor pharmacology-A focus on mutations in the loops and C-terminus.Semantic proximity Read ↗

Cancer-Related Somatic Mutations in Transmembrane Helices Alter Adenosine A1 Receptor Pharmacology.Semantic proximity Read ↗

Cancer-Associated Mutations of the Adenosine A2A Receptor Have Diverse Influences on Ligand Binding and Receptor Functions.Semantic proximity Read ↗

Random mutagenesis of the human adenosine A2B receptor followed by growth selection in yeast. Identification of constitutively active and gain of function mutations.Semantic proximity Read ↗

Scanning mutagenesis in a yeast system delineates the role of the NPxxY(x)(5,6)F motif and helix 8 of the adenosine A(2B) receptor in G protein coupling.Semantic proximity Read ↗

Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors.Semantic proximity Read ↗

ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor.Semantic proximity Read ↗

Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled receptors expressed in tumors.Semantic proximity Read ↗

Pan-cancer in silico analysis of somatic mutations in G-protein coupled receptors: The effect of evolutionary conservation and natural varianceSemantic proximity Read ↗

Domains for activation and inactivation in G protein-coupled receptors--a mutational analysis of constitutive activity of the adenosine A2B receptor.Semantic proximity Read ↗

Unintended Effects of GPCR-Targeted Drugs on the Cancer Phenotype.Semantic proximity Read ↗

G Protein-Coupled Receptors in CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.