Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Screening for novel constitutively active CXCR2 mutants and their cellular effects.

Methods in enzymology - 1 Jan 2010

Park Giljun, Masi Tom, Choi Chang K, Kim Heejung, Becker Jeffrey M, Sparer Tim E

Abstract excerpt

Chemokines play an important role in inflammatory, developmental, and homeostatic processes. Deregulation of this system results in various diseases including tumorigenesis and cancer metastasis. Deregulation can occur when constitutively active mutant (CAM) chemokine receptors are locked in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Electric Impedance
Share to Genes, Reporter

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luciferases

Share to Mutagenesis

Share to NIH 3T3 Cells

Share to Receptors, Interleukin-8B

Share to Transfection

Source

Identifiers

PMID: 21050933
DOI: 10.1016/B978-0-12-381296-4.00026-9

Genes

CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21050933-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Screening for novel constitutively active CXCR2 mutants and their cellular effects.PMID 21050933Read ↗

Functional expression of CXCR4 in S. cerevisiae: development of tools for mechanistic and pharmacologic studies.Semantic proximity Read ↗

Constitutively active chemokine CXC receptors.Semantic proximity Read ↗

A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists.Semantic proximity Read ↗

Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2.Semantic proximity Read ↗

Ligand rescue of constitutively active mutant receptors.Semantic proximity Read ↗

Developing chemokine mutants with improved proteoglycan affinity and knocked-out GPCR activity as anti-inflammatory recombinant drugs.Semantic proximity Read ↗

Site-directed mutagenesis of the CC chemokine binding protein 35K-Fc reveals residues essential for activity and mutations that increase the potency of CC chemokine blockade.Semantic proximity Read ↗

A constitutively active GPCR retains its G protein specificity and the ability to form dimers.Semantic proximity Read ↗

Constitutively active G protein-coupled receptor mutants: implications on receptor function and drug action.Semantic proximity Read ↗

Uveal Melanoma Oncogene <i>CYSLTR2</i> Encodes a Constitutively Active GPCR Highly Biased Toward Gq SignalingSemantic proximity Read ↗

Impact of cancer-associated mutations in CC chemokine receptor 2 on receptor function and antagonism.Semantic proximity Read ↗

GPCR Inhibition in Treating LymphomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.