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Article

Structural insight to mutation effects uncover a common allosteric site in class C GPCRs.

Bioinformatics (Oxford, England) - 15 Apr 2017

Harpsøe Kasper, Boesgaard Michael W, Munk Christian, Bräuner-Osborne Hans, Gloriam David E

Abstract excerpt

Motivation: Class C G protein-coupled receptors (GPCRs) regulate important physiological functions and allosteric modulators binding to the transmembrane domain constitute an attractive and, due to a lack of structural insight, a virtually unexplored potential for therapeutics and the food industry. Combining pharmacological site-directed mutagenesis data with the recent class C GPCR experimental structures will...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28011766
DOI: 10.1093/bioinformatics/btw784
PMCID: PMC5408886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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