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Article

The effect of cancer-associated mutations on ligand binding and receptor function - A case for the 5-HT2C receptor.

European journal of pharmacology - 15 Dec 2024

Feng Chenlin, Liu Rongfang, Brooks Reno, Wang Xuesong, Jespers Willem, Gorostiola González Marina, Westen Gerard J P van, Danen Erik H J, Heitman Laura H

Abstract excerpt

The serotonin 5-HT2C receptor is a G protein-coupled receptor (GPCR) mainly expressed in the central nervous system. Besides regulating mood, appetite, and reproductive behavior, it has been identified as a potential target for cancer treatment. In this study, we aimed to investigate the effects of cancer patient-derived 5-HT2C receptor mutations on ligand binding and receptor functionality. By filtering the...

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PMID: 39481631
DOI: 10.1016/j.ejphar.2024.177081

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