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Article

Accurate genome-wide genotyping from archival tissue to explore the contribution of common genetic variants to pre-cancer outcomes.

Journal of translational medicine - 27 Dec 2022

Nachmanson Daniela, Pagadala Meghana, Steward Joseph, Cheung Callie, Bruce Lauryn Keeler, Lee Nicole Q, O'Keefe Thomas J, Lin Grace Y, Hasteh Farnaz, Morris Gerald P, Carter Hannah, Harismendy Olivier

Abstract excerpt

PURPOSE: The contribution of common genetic variants to pre-cancer progression is understudied due to long follow-up time, rarity of poor outcomes and lack of available germline DNA collection. Alternatively, DNA from diagnostic archival tissue is available, but its somatic nature, limited quantity and suboptimal quality would require an accurate cost-effective genome-wide germline genotyping methodology....

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Source

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Identifiers

PMID: 36575447
DOI: 10.1186/s12967-022-03810-z
PMCID: PMC9793518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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