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Generalizability of PGS313 for breast cancer risk in a Los Angeles biobank.

HGG advances - 18 Jul 2024

Shang Helen, Ding Yi, Venkateswaran Vidhya, Boulier Kristin, Kathuria-Prakash Nikhita, Malidarreh Parisa Boodaghi, Luber Jacob M, Pasaniuc Bogdan

Abstract excerpt

Polygenic scores (PGSs) summarize the combined effect of common risk variants and are associated with breast cancer risk in patients without identifiable monogenic risk factors. One of the most well-validated PGSs in breast cancer to date is PGS313, which was developed from a Northern European biobank but has shown attenuated performance in non-European ancestries. We further investigate the generalizability of...

Topics

Humans
Breast Neoplasms
Female
Biological Specimen Banks
Los Angeles
Genetic Predisposition to Disease
Middle Aged
Risk Factors
Multifactorial Inheritance
ROC Curve
Adult

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Aged

Polymorphism, Single Nucleotide

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Open in PubMed Open full text

Identifiers

PMID: 38704641
DOI: 10.1016/j.xhgg.2024.100302
PMCID: PMC11137525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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