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Article

High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases.

Laboratory investigation; a journal of technical methods and pathology - 1 Apr 2024

Youssef Omar, Loukola Anu, Zidi-Mouaffak Yossra H S, Tamlander Max, Ruotsalainen Sanni, Kilpeläinen Elina, Mars Nina, Ripatti Samuli, Palotie Aarno, Donner Kati, Carpén Olli

Abstract excerpt

Formalin-fixed paraffin-embedded (FFPE) tissues stored in biobanks and pathology archives are a vast but underutilized source for molecular studies on different diseases. Beyond being the "gold standard" for preservation of diagnostic human tissues, FFPE samples retain similar genetic information as matching blood samples, which could make FFPE samples an ideal resource for genomic analysis. However, research on...

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PMID: 38220043
DOI: 10.1016/j.labinv.2024.100325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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