Article

Low-pass Whole Genome Imputation Enables the Characterization of Polygenic Breast Cancer Risk in the Indigenous Arab Population

2022-12-09

Abstract excerpt

The indigenous Arab population has traditionally been underrepresented in cancer genomics studies, and as a result the polygenic risk landscape of breast cancer in the population remains elusive. Here we show by utilizing low-pass whole genome sequencing (lpWGS), we can accurately impute population-specific variants with high exome concordance (median dosage correlation: 0.9459, Interquartile range: 0.9410-0.9490)...

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Literature Corpus work: 07bf398f-3ed2-5d80-9df7-49571696359e
DOI: 10.1101/2022.12.07.22282785

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