Article

Genetic assessments of breast cancer risk that do not account for polygenic background are incomplete and lead to incorrect preventative strategies

2021-08-23

Abstract excerpt

Breast cancer is the most common cancer among women and is a leading cause of cancer mortality worldwide. There is a significant genetic component to breast cancer risk which is the result of both rare pathogenic mutations and common genome-wide variation. However, the penetrance of pathogenic mutations varies widely and their frequency is low, both at a population level and amongst breast cancer cases. Polygenic...

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Literature Corpus work: df3065b6-4fdf-57b8-999d-a85f6d7c1f85
DOI: 10.1101/2021.08.13.21262050

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