Leveraging expression quantitative trait loci information in single-cell resolution to identify cell-specific genes for Basal cell carcinoma.

Abstract excerpt

BACKGROUND: Basal cell carcinoma (BCC), the most common skin cancer, is driven by UV-induced DNA damage and shaped by immune surveillance. Although GWAS has identified over 140 risk loci, their cell-type-specific effects remain obscured by tissue-level averaging. METHODS: We integrated BCC GWAS summary statistics from a UK-based cohort (17,416 cases, 375,455 controls) with single-cell expression quantitative...

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