Article

Germline rare deleterious variant load alters cancer risk, age of onset and tumor characteristics

2021-07-07

Abstract excerpt

<h4>Background</h4> Inherited genetic variants play an important role in cancer susceptibility. Recent studies show that rare, deleterious variants (RDVs) in a few genes are critical determinants of heritable cancer risk. Better understanding of germline RDVs will contribute to improved precision prevention, screening and treatment. <h4>Methods</h4> We have performed the largest to date jointly processed germline...

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Literature Corpus work: bd8b52fb-6ffe-5a4f-b146-c0cdb7f12e05
DOI: 10.1101/2021.07.02.21259537

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