Article

Constructing germline research cohorts from the discarded reads of clinical tumor sequences

2021-04-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Hundreds of thousands of cancer patients have had targeted (panel) tumor sequencing to identify clinically meaningful mutations. In addition to improving patient outcomes, this activity has led to significant discoveries in basic and translational domains. However, the targeted nature of clinical tumor sequencing has a limited scope, especially for germline genetics. In this w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4259b22b-1631-57c5-a50d-127de4406593
DOI: 10.1101/2021.04.09.21255197

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Constructing germline research cohorts from the discarded reads of clinical tumor sequencesDOI 10.1101/2021.04.09.21255197Read

Constructing germline research cohorts from the discarded reads of clinical tumor sequences.Semantic proximity Read

Germline sequencing for presumed germline pathogenic variants via tumor-only comprehensive genomic profilingSemantic proximity Read

Germline testing data validate inferences of mutational status for variants detected from tumor-only sequencingSemantic proximity Read

The impact of tumor profiling approaches and genomic data strategies for cancer precision medicineSemantic proximity Read

Pan-Cancer Analysis Reveals Technical Artifacts in TCGA Germline Variant CallsSemantic proximity Read

Germline rare deleterious variant load alters cancer risk, age of onset and tumor characteristicsSemantic proximity Read

Evaluating the molecular diagnostic yield of joint genotyping-based approach for detecting rare germline pathogenic and putative loss-of-function variants.Semantic proximity Read

Accurate genome-wide genotyping from archival tissue to explore the contribution of common genetic variants to pre-cancer outcomes.Semantic proximity Read

A method to reduce ancestry related germline false positives in tumor only somatic variant callingSemantic proximity Read

A consensus-based classification workflow to determine genetically inferred ancestry from comprehensive genomic profiling of patients with solid tumors.Semantic proximity Read

Genetic Ancestry Inference from Cancer-Derived Molecular Data across Genomic and Transcriptomic Platforms.Semantic proximity Read

Germline Testing Data Validate Inferences of Mutational Status for Variants Detected From Tumor-Only Sequencing.Semantic proximity Read