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Article

Constructing germline research cohorts from the discarded reads of clinical tumor sequences.

Genome medicine - 8 Nov 2021

Gusev Alexander, Groha Stefan, Taraszka Kodi, Semenov Yevgeniy R, Zaitlen Noah

Abstract excerpt

BACKGROUND: Hundreds of thousands of cancer patients have had targeted (panel) tumor sequencing to identify clinically meaningful mutations. In addition to improving patient outcomes, this activity has led to significant discoveries in basic and translational domains. However, the targeted nature of clinical tumor sequencing has a limited scope, especially for germline genetics. In this work, we assess the...

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Identifiers

PMID: 34749793
DOI: 10.1186/s13073-021-00999-4
PMCID: PMC8576948

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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