Article
Germline Variation and Breast Cancer Incidence: A Gene-Based Association Study and Whole-Genome Prediction of Early-Onset Breast Cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2018
Scannell Bryan Molly, Argos Maria, Andrulis Irene L, Hopper John L, Chang-Claude Jenny, Malone Kathleen E, John Esther M, Gammon Marilie D, Daly Mary B, Terry Mary Beth, Buys Saundra S, Huo Dezheng, Olopade Olofunmilayo I, Genkinger Jeanine M, Whittemore Alice S, Jasmine Farzana, Kibriya Muhammad G, Chen Lin S, Ahsan Habibul
Abstract excerpt
Background: Although germline genetics influences breast cancer incidence, published research only explains approximately half of the expected association. Moreover, the accuracy of prediction models remains low. For women who develop breast cancer early, the genetic architecture is less established.Methods: To identify loci associated with early-onset breast cancer, gene-based tests were carried out using exome...
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