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Article

Improved two-step testing of genome-wide gene-environment interactions.

Genetic epidemiology - 1 Mar 2023

Kawaguchi Eric S, Kim Andre E, Lewinger Juan Pablo, Gauderman W James

Abstract excerpt

Two-step tests for gene-environment ( G × E $G\times E$ ) interactions exploit marginal single-nucleotide polymorphism (SNP) effects to improve the power of a genome-wide interaction scan. They combine a screening step based on marginal effects used to "bin" SNPs for weighted hypothesis testing in the second step to deliver greater power over single-step tests while preserving the genome-wide Type I error....

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Identifiers

PMID: 36571162
DOI: 10.1002/gepi.22509
PMCID: PMC9974838

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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