Article
Marginal interaction test for detecting interactions between genetic marker sets and environment in genome-wide studies.
G3 (Bethesda, Md.) - 8 Jan 2025
Shen Linchuan, Amei Amei, Liu Bowen, Xu Gang, Liu Yunqing, Oh Edwin C, Zhou Xin, Wang Zuoheng
Abstract excerpt
As human complex diseases are influenced by the interaction between genetics and the environment, identifying gene-environment interactions (G×E) is crucial for understanding disease mechanisms and predicting risk. Developing robust quantitative tools for G×E analysis can enhance the study of complex diseases. However, many existing methods that explore G×E focus on the interplay between an environmental factor...
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