Article
Exploiting gene-environment interaction to detect genetic associations.
Human heredity - 1 Jan 2007
Kraft Peter, Yen Yu-Chun, Stram Daniel O, Morrison John, Gauderman W James
Abstract excerpt
Complex disease by definition results from the interplay of genetic and environmental factors. However, it is currently unclear how gene-environment interaction can best be used to locate complex disease susceptibility loci, particularly in the context of studies where between 1,000 and 1,000,000 markers are scanned for association with disease. We present a joint test of marginal association and gene-environment...
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