Article
Powerful Set-Based Gene-Environment Interaction Testing Framework for Complex Diseases.
Genetic epidemiology - 1 Dec 2015
Jiao Shuo, Peters Ulrike, Berndt Sonja, Bézieau Stéphane, Brenner Hermann, Campbell Peter T, Chan Andrew T, Chang-Claude Jenny, Lemire Mathieu, Newcomb Polly A, Potter John D, Slattery Martha L, Woods Michael O, Hsu Li
Abstract excerpt
Identification of gene-environment interaction (G × E) is important in understanding the etiology of complex diseases. Based on our previously developed Set Based gene EnviRonment InterAction test (SBERIA), in this paper we propose a powerful framework for enhanced set-based G × E testing (eSBERIA). The major challenge of signal aggregation within a set is how to tell signals from noise. eSBERIA tackles this...
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