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Article

Simultaneously testing for marginal genetic association and gene-environment interaction.

American journal of epidemiology - 15 Jul 2012

Dai James Y, Logsdon Benjamin A, Huang Ying, Hsu Li, Reiner Alexander P, Prentice Ross L, Kooperberg Charles

Abstract excerpt

In this article, the authors propose to simultaneously test for marginal genetic association and gene-environment interaction to discover single nucleotide polymorphisms that may be involved in gene-environment or gene-treatment interaction. The asymptotic independence of the marginal association estimator and various interaction estimators leads to a simple and flexible way of combining the 2 tests, allowing for...

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Identifiers

PMID: 22771729
DOI: 10.1093/aje/kwr521
PMCID: PMC3499112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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