Article
Chronic running-wheel exercise from adolescence leads to increased anxiety and depression-like phenotypes in adulthood in rats: Effects on stress markers and interaction with BDNF Val66Met genotype.
Developmental psychobiology - 1 Jan 2023
Jaehne Emily J, Kent Jessica N, Lam Nikki, Schonfeld Lina, Spiers Jereme G, Begni Veronica, De Rosa Federico, Riva Marco A, van den Buuse Maarten
Abstract excerpt
Exercise has been shown to be beneficial in reducing symptoms of affective disorders and to increase the expression of brain-derived neurotrophic factor (BDNF). The BDNF Val66Met polymorphism is associated with reduced activity-dependent BDNF release and increased risk for anxiety and depression. Male and female Val66Met rats were given access to running wheels from 3 weeks of age and compared to sedentary...
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