Article
Deficit in BDNF does not increase vulnerability to stress but dampens antidepressant-like effects in the unpredictable chronic mild stress.
Behavioural brain research - 14 Sept 2009
Ibarguen-Vargas Yadira, Surget Alexandre, Vourc'h Patrick, Leman Samuel, Andres Christian R, Gardier Alain M, Belzung Catherine
Abstract excerpt
Despite growing evidences of an association between brain-derived neurotrophic factor (BDNF) and antidepressant effects, the neurotrophic hypothesis of depression is challenged by the paucity of direct links between BDNF deficit and depressive-like behaviors. The unpredictable chronic mild stress (UCMS) paradigm might take our understanding a step further by examining whether a decrease in bdnf expression can...
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