Article
Biomaterial mediated simultaneous delivery of spermine and alpha ketoglutarate modulate metabolism and innate immune cell phenotype in sepsis mouse models.
Biomaterials - 1 Feb 2023
Inamdar Sahil, Tylek Tina, Thumsi Abhirami, Suresh Abhirami P, Jaggarapu Madhan Mohan Chandra Sekhar, Halim Michelle, Mantri Shivani, Esrafili Arezoo, Ng Nathan D, Schmitzer Elizabeth, Lintecum Kelly, de Ávila Camila, Fryer John D, Xu Ying, Spiller Kara L, Acharya Abhinav P
Abstract excerpt
Although different metabolic pathways have been associated with distinct macrophage phenotypes, the field of utilizing metabolites to modulate macrophage phenotype is in a nascent stage. In this report, we developed microparticles based on polymerization of alpha-ketoglutarate (a Krebs cycle metabolite), with or without encapsulation of spermine (a polyamine metabolite), to modulate cell phenotype that are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.