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Article

Rational Design of Advanced Gene Delivery Carriers: Macrophage Phenotype Matters.

Advanced materials (Deerfield Beach, Fla.) - 1 Jan 2025

Wang Yue, Yao Yining, Zhang Yue, Yu Yingjie, Luo Jiangqi, Sweet Matthew J, Yu Chengzhong

Abstract excerpt

Nucleic acid delivery in hard-to-transfect macrophages have attracted increasing attention in diverse applications such as defence against bacterial infection. Regulated by microenvironments in specific applications, macrophages have a heterogenous nature and exist in different phenotypes with diverse functions, e.g., pro-inflammatory and anti-inflammatory. However, it is not clear whether macrophage phenotype...

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PMID: 39558810
DOI: 10.1002/adma.202401504

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