Article

Development of itaconate polymer microparticles for intracellular regulation of pro-inflammatory macrophage activation

2025-02-05

Abstract excerpt

Itaconate (IA) is an endogenous metabolite and a potent regulator of the innate immune system. Its use in immunomodulatory therapies has faced limitations due to inherent challenges in achieving controlled delivery and requirements for high extracellular concentrations to achieve internalization of the highly polar small molecule to achieve its intracellular therapeutic activity. Microparticle (MP)-based delivery...

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Literature Corpus work: 7b9ac9e8-fcaf-500b-9d4d-61345e1a34d9
DOI: 10.1101/2025.01.30.635692

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