Article
Improvement in phenotype homeostasis of macrophages by chitosan nanoparticles and subsequent impacts on liver injury and tumor treatment.
Carbohydrate polymers - 1 Feb 2022
Jiang Liqun, Wang Yun, Wei Xiangrong, Yang Ling, Liu Shuo, Wang Yan, Xu Ya, Wang Ziyao, Zhang Cong, Zhang Mi, Zhang Yudong, Jin Fang, Yin Xiaoxing
Abstract excerpt
When organic polymer-based drug nanocarriers become concentrated in macrophages, their influence on macrophage polarization has been rarely reported. This study prepared chitosan-based nanoparticles (CNs, 181.5 nm, +14.83 mV) and detected their impacts on macrophage reprogram. RT-PCR results showed in M1-like RAW264.7 cells (Mφ1), CNs decreased CD86 and iNOS expressions by 53.8% and 57.1%, and increased Arg-1 and...
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