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Article

Glycolytic reprogramming in macrophages and MSCs during inflammation

22 Aug 2023

Abstract excerpt

Background: Dysregulated inflammation is associated with many skeletal diseases and disorders, such as osteolysis, non-union of fractures, osteonecrosis, osteoarthritis and orthopaedic infections. We previously showed that continuous infusion of lipopolysaccharide (LPS) contaminated polyethylene particles (cPE) caused prolonged inflammation and impaired bone formation. However, the metabolic and bioenergetic...

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PMID: 37675119
DOI: 10.3389/fimmu.2023.1199751

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